South Carolina 
SC Organizations SC Animal Organizations Upstate Animal Rescue Organizations
These animal rescue organizations – located in the upstate of South Carolina – provide care and refuge for cats, dogs, horses, rabbits, and other domestic animals.
If you have a wild animal that is injured or orphaned, please visit our
SC Wildlife Rescue page.
Upstate Animal Protection & Rescue Organizations
- Anderson County PAWS - Anderson
- Anderson County Humane Society - Anderson
- Animal Allies - Spartanburg - low cost spay neuter clinic
- Animal Rescue Fund of South Carolina - Seneca
- Big Oaks Rescue Farm - Hodges - donkey, mule, horse, and some other farm animal rescue
- Boykin Spaniel Rescue - Boiling Springs
- Bullies 2 the Rescue - based in Unionville, NC but also serves SC - english and french bulldog rescue
- Carolina Poodle Rescue - Spartanburg
- Concerned Citizens for Animals - Simpsonville
- Critter Connection - Spartanburg
- Day Before The Rainbow - Greer
- Diamond in the Ruff Rescue & Rehab - Seneca - pit rescue
- Foothills Golden Retriever Rescue - Greenville
- Foster Paws Rescue - Lyman - saving the lives of homeless cats in the upstate through aggressive spay, neuter, adoptions, and education
- Freedom Train Animal Rescue Transports - Anderson - volunteers transport at-risk animals to safe locations
- Greenville County Animal Care - Greenville
- Greenville Humane Society - Greenville
- Greyhound Crossroads - Greenwood
- Hasty's Haven Rescue - Liberty - horse and donkey rescue
- Hollow Creek Farm Equine and Canine Rescue - York County
- Humane Society of Greenwood - Greenwood
- Humane Society of Lancaster
- Humane Society of McCormick County - McCormick
- Humane Society of York County - Fort Mill
- Infinity Paws Animal Advocacy - Woodruff
- KitsNKats Rescue - Easley
- k9.5 Rescue - Greenville - volunteers focus on Great Pyrenees, other giant breeds, seniorsm and special needs animals
- Lancaster SPCA
- Laurens County Animal Care - Laurens
- Laurens County Humane Society - Clinton
- Lily's Haven Equine & Rescue Facility - Lancaster - horses, goats, donkeys, other farm animals plus educational opportunities, boarding, training
- Lucky Dog Rescue - Gaffney
- Lucky Pup Rescue - Greenville
- Me And YOUnicorn - Fountain Inn - horse rescue
- New Beginnings Shepherd Rescue - Pelzer
- Oconee County Humane Society - Walhalla
- Operation CARE - Rock Hill
- Pet Tender Angels Rescue and Rehabilitation - Greenville
- Phoenix Rising Border Collie Rescue
- Pickens County Animal Shelter
- Pickens County Humane Society
- Pilots N Paws - Landrum - pilots and other volunteers help transport rescue animals by air
- Purrbabies Rescue - Greenville
- Purrs, Paws, and Claws - Belton
- Reviving Reptiles Rescue - Gaffney
- Richardson Rescue - York
- Second Hand Sanctuary - Marietta - transport, rescue, rehabilitation, and placement of domestic animals and small livestock
- Spartanburg Humane Society
- Speak for Animals - Greenville
- Stone Soup Animal Rescue - Woodruff
- Upstate Animal Rescue Foundation of South Carolina - working in Anderson, Pickens, Greenville, and Oconee counties
- Wild Pines Sanctuary - Union - farm animal rescue and sanctuary
